Academic Publications

Published Researches

Dr Aydin's research programme examines QEEG-derived measures and non-invasive neuromodulation in neurodevelopmental populations, including autism spectrum disorder. Publication status, study design and methodological limitations are stated individually for each work.

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Research Focus

QEEG is used within this research as a quantitative neurophysiological and longitudinal monitoring method. It is not presented as a stand-alone diagnostic test for autism or as proof of treatment efficacy.

The research investigates neurophysiological change, individual variability and the potential role of QEEG-derived information in personalised assessment and clinical research. Findings are interpreted within the limitations of each study design and do not establish guaranteed clinical benefit for an individual patient.

Methodology & Approach

Dr Aydin's peer-reviewed research examines QEEG-guided neuromodulation, electrophysiological change and individual variability in autism spectrum disorder. This work contributes to a developing evidence base and informs ongoing investigation into how objective neurophysiological measures may support individualised clinical assessment, research and longitudinal monitoring.

The research does not establish that neuromodulation cures autism or guarantees improvement in any individual clinical feature.

Research Areas

  • QEEG Brain Mapping
  • rTMS for ASD
  • tDCS Protocols
  • Excitation-Inhibition Balance
  • Social Communication
  • Home-Based Neuromodulation

Research Collaboration

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2025 Publications

November 2025 Article · Full-text available

Mixed-Frequency rTMS Rapidly Modulates Multiscale EEG Biomarkers of Excitation–Inhibition Balance in Autism Spectrum Disorder: A Single-Case Report

Alptekin Aydin

Background: Repetitive transcranial magnetic stimulation (rTMS) is an established neuromodulatory method, yet its multiscale neurophysiological effects in autism spectrum disorder (ASD) remain insufficiently characterized. Recent EEG analytic advances—such as spectral parameterization, long-range temporal correlation (LRTC) assessment, and connectivity analysis—offer new insights into excitation-inhibition balance and neural dynamics that may clarify how rTMS exerts its effects.

Methods: We present a single-case study of a young adult male with ASD who underwent a mixed-frequency rTMS protocol targeting the dorsolateral prefrontal cortex (DLPFC). QEEG assessments were conducted pre- and post-intervention using a 19-channel montage. We analyzed spectral power, aperiodic (1/f) slope, theta/beta ratio (TBR), detrended fluctuation analysis (DFA) exponents, and coherence/phase-lag index (PLI) metrics.

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October 2025 Article · Full-text available

QEEG-Guided rTMS in Pediatric ASD with Contextual Evidence on Home-Based tDCS: Within-Cohort Reanalysis and Narrative Contextualization

Alptekin Aydin

Background: Autism Spectrum Disorder (ASD) affects approximately 1 in 36 children and is increasingly studied as a candidate for non-invasive neuromodulation. Two of the most widely applied modalities are quantitative EEG (QEEG)-guided repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS), both targeting the dorsolateral prefrontal cortex (DLPFC).

This study presents a within-cohort reanalysis of QEEG-guided rTMS outcomes in pediatric ASD, contextualized alongside emerging evidence for home-based tDCS interventions. The research examines treatment response patterns, optimal dosing parameters, and the role of baseline QEEG characteristics in predicting outcomes.

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January 2025 Article · Full-text available

Comparative Efficacy of QEEG-Guided rTMS and Home-Based tDCS for Social Communication and Behavioral Outcomes in Autism Spectrum Disorder: A Parallel Cohort Analysis

Alptekin Aydin

This study examines deficits manifesting as social emotional reciprocity: diminished sharing of affect, failure of back-and-forth conversation, or reduced interest in peers. It investigates nonverbal communicative behaviours including atypical eye gaze, facial expressions, prosody, or gesture integration, as well as difficulties in developing, maintaining and understanding relationships.

Using parallel cohort methodology, this research directly compares outcomes between clinic-based QEEG-guided rTMS and supervised home-based tDCS protocols, providing valuable insights into the relative efficacy and practical considerations of each approach for families and clinicians.

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Access All Publications

All research papers are available in full-text on ResearchGate. For research collaboration enquiries, clinical consultations, or media requests, please get in touch.

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